This trend could be due to greater logistical challenges in administering directly observed NTX when patients transitioned to outpatient care, as they increased their binge drinking (zapoi) and tended to miss daily appointments.
There are greater logistical challenges, such as identifying and locating eligible children who are scattered throughout a relatively large geographic area, selecting among them in an unbiased way, and the need for mobile, trained teams to collect their data.
The greatest logistical challenge is maintaining an Internet connection.
Dealing with the site is the greatest logistical challenge the city has faced in modern times, and deciding how to handle this challenge is, in effect, a referendum about what the city's symbolic center should be.
Previously Royal Mail had statement the greater number of Paralympic gold medals expected made it too difficult to produce a stamp for every winner and Hammond said it would be the "greatest logistical challenge in stamps production ever undertaken" by any postal administration.
The introduction of euro notes and coins was described, by government officials as well as the news media, as one of the greatest peacetime logistical challenges that Europe had ever confronted.
Organizing the march is a logistical challenge, but out of great challenges come great rewards.
While Tuesday's memorial service will clearly be a big organisational challenge, the state funeral will be a greater logistical one because of its rural remoteness, BBC correspondent Mike Woodridge reports.
We recognize that the use of SILAC would provide greater precision, but a protein of such low cellular abundance as Cse4 presents a logistical challenge for future consideration.
Now 61, he seems to revel in the complexities of a capital case, pushing a great wave of white hair out of the way as he dispenses with one legal or logistical challenge after another.
