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By definition, all subjects with CFS POTS reported severe fatigue, which was greater in severity than in those without CFS (51±1 compared with 43±3 respectively; P=0.016).
"A lot of the issues facing Citigroup are not new issues, they have simply grown greater in severity," said Michael Mayo, an analyst at Deutsche Bank.
We compared clinically-significant symptoms (rated as four or greater in severity) between hematologic and solid tumor patients and performed multivariate logistic regression analyses examining the relationship between symptom burden and tumor type.
These T2DM patients exhibit symmetrical lipodystrophy of the distal limbs, acanthosis nigricans, marked insulin resistance with little insulin-mediated glucose uptake, hypertriglyceridemia, and hepatic transaminase elevations, which are greater in severity than observed in patients with common T2DM.
They also manifest a profound degree of insulin resistance and marked elevations in hepatic transaminases (indicative of hepatic steatosis) and triglycerides, which are greater in severity than in patients with commonly occurring T2DM lacking PLL.
These patients exhibit symmetrical lipodystrophy of the distal limbs, acanthosis nigricans, earlier onset T2DM, and marked insulin resistance with little insulin-mediated glucose uptake, as well as hypertriglyceridemia and hepatic transaminase elevations that are greater in severity than observed in patients with commonly occurring T2DM.
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In non-DPN subjects a 40% greater reduction in severity was observed in Celliant™ subjects (p = 0.230).
Moreover the ED's high patient flow with its great diversity in severity of symptoms, makes it hard for ED staff to calmly discuss a suspicion of child abuse with parents.
Although each Fragile X-associated condition does have a characteristic phenotype, great variability exists in severity and penetrance.
It has been observed that mutations in TSC2 result in greater severity of renal disease, and a number of studies have analysed the genotype phenotype correlations [ 8, 9].
The challenges that confront China, America's putative superpower replacement, are far greater in number and severity.
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