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These findings show that the MTHFR C677T variant is associated with greater depressed mood during pregnancy.
Higher scores of CES-DK indicate greater depressed mood, a finding validated in a Korean population [ 16].
Responses are summed to produce a total score ranging from 0 to 60, with higher scores indicating greater depressed mood.
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First we found that that 2nd trimester maternal depressed mood symptoms scores are associated with maternal MTHFR C677T genotype, such that women with the MTHFR 677TT genotype have the greatest depressed mood symptoms.
However, sleep deprivation, as reflected by percentage of total sleep duration <7 hrs (39.0% vs. 21.5%, p=0.008) and insomnia symptoms (55.9% vs. 30.4%, p=0.0004), was greater for depressed women only at 20 weeks gestation compared with non-depressed ones.
Given we found the MTHFR C677T variant is associated with greater antenatal depressed mood symptoms in women and that the SLC6A4 promoter methylation status in women and infants was affected by maternal mood our finding of no direct effect of the MTHFR C677T variant on SLC6A4 promoter methylation status was unexpected.
The researchers found that right amygdala and right thalamus activity was significantly greater in the depressed children than in the others, a finding that has also been observed in depressed adolescents and adults.
These women also displayed greater increases in depressed mood throughout the day, greater fatigue in the evening and experienced a more difficult transition from work to home.
Despite these limitations, the results from this study show that presence of chronic illness is associated with substantially reduced general QOL and happiness, and greater levels of depressed mood across a wide range of conditions suggesting that the presence of chronic illness is not limited to function related impairments only but may have broader implications.
A score of 10 or greater is considered depressed.
A score of 6 or greater indicates a depressed mood [ 40, 41].
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