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Alginate constructs accumulated significantly more mineral and supported greater bone formation in central regions of the engineered tissue.
Equally, in another controlled prospective cohort, greater bone formation was found when BMP-7 was used with allograft compared with allograft alone.
TCP-P displayed better surgical handling properties, greater bone formation, higher expression of Col I, ALP, OC and BSP; as well as significantly lower grafting volume reduction values.
Here, oscillatory accelerations resulted in greater bone formation in trabecular compartments and in enhanced bone morphology.
Oscillatory accelerations, applied in the absence of weight bearing, resulted in 70% greater bone formation rates in the trabeculae of the metaphysis, but similar levels of bone resorption, when compared to contralateral controls.
This finding is consistent with a Y1 receptor-mediated action in the periphery, since hypothalamus-specific deletion of Y1 receptors did not replicate the greater bone formation evident in germline Y1−/− mice [10].
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In the study group, the greatest bone formation was observed in the CGF-treated group but this difference was not statistically significant [38].
Zhao et al. [ 29] demonstrated that a BMP-2-absorbed monoclonal antibodies conjugated DBM (MAbs-DBM) group experienced greater osteogenic differentiation in an in vitro study and greater ectopic bone formation in an in vivo study than the control group.
The histological analysis showed that the solid fixation in both groups was obtained in a different way for each group: the HA-coated implants had a greater surface bone ongrowth, whereas the growth factor-coated Ti implants had greater new bone formation in the surrounding gap.
The 20/80 HA/TCP composition was chosen as the ceramic component because of previous reports of greater bone tissue formation in comparison with HA or TCP alone.
Osteoporosis occurs when bone remodeling process, the process that normally occurs throughout life to control the repair or replacement of bone following injuries, is imbalanced with a net bone resorption greater than bone formation at bone multicellular units (BMUs) [1 3].
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