The greater tolerability of sertraline is an important consideration because of the chronicity of dysthymia, which may require prolonged treatment with antidepressant medication.
OXC has a comparable efficacy to that of CBZ but a greater tolerability and a lower potential for drug interaction [23 25].
Accordingly, investigators rated the tolerability of both interventions equally during the first 15 days of treatment but considered that at days 30 and 90, treatment with HA and physical therapy had greater tolerability than physical therapy only (Fig. 3d).
Mirtazapine, SSRI (fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram and escitalopram) or SNRI (venlafaxine, duloxetine) should be preferred because of their greater tolerability profile in comparison with tricyclics, even if controlled and randomized studies of elderly tension-type headache are lacking.
One explanation for this is the greater tolerability of nonsense mutations when present in a heterozygote.
Polymeric micelles on other hand, offer greater advantage in terms of solubilization capacity, lower CMC and greater tolerability.
The 15 mg/day dose, lowest of the recommended range, appears to offer the greatest tolerability while providing efficacy.
The benefits of preoperative therapy in colon cancer, although theoretically persuasive (potential downstaging, greater tolerability), remain unproven.
Temozolomide has largely replaced PCV (procarbazine, CCNU, and vincristine) as the chemotherapeutic agent for AO and AOA, largely due to greater tolerability and less potential for toxicity.
