However, starting from the late 1940s and early 1950s, Istanbul underwent great structural change, as new public squares, boulevards, and avenues were constructed throughout the city, sometimes at the expense of historical buildings.
This finding suggested that the C122 area was likely to undergo greater structural changes compared with the C164 residue area.
Urban females have experienced the greatest structural changes in disease patterns and mortality transition compared to other population categories and are leading in epidemiological transition.
On the other hand, GlpG was preferably targeted if the N-sulfonyl substituent was replaced (e.g., L8, L29), suggesting that GlpG could tolerate greater structural changes at this position.
He is also making big structural changes.
The NHS is already undergoing arguably the greatest structural change of any public sector organisation: figures from the Royal College of Nursing show 56,000 posts have been lost across the UK since 2010.
The greatest structural change induced from exposure of the samples to IPA was observed at higher IPA concentrations.
X-ray crystallography data were also consistent with the NMR observation, in which most of the changes in chemical shift took place in the residues close to C122, and this area was likely to undergo greater structural change than in the C164 residue area (Fig. 3B).
However, α-syn appears to induce a greater structural change in Aβ42.
The most significant change is probably the proline-to-leucine amino acid change leading to a greater structural change and the function of the protein.
