They can trigger efficient silencing of one or several genes or specific alleles with great specificity, even for genes essentially inaccessible to other reverse genetics techniques, e.g., tandem duplicated genes.
Thus having antibodies that can recognize the different isoforms of CCN proteins with great specificity and in respect to specific epitopes within the domains would be invaluable for quantitation [ 40] and for dissecting their functions in communication signaling.
Although most histological diagnoses are made with relative ease and with great specificity and reproducibility, there is a subset of cases in which a specific and reproducible diagnosis is difficult or even impossible to render.
What they provide, with great specificity, is a guide to the ingredients of civil society".
Recorded with great specificity of timbre, solo instruments sound like the very essence of themselves.
Mr. Hilal spoke with great specificity, and several incidents he described were corroborated by Tulkarm residents.
With great specificity, the concerns of these and other interest groups were brought inside the Oval Office by Obama's aides.
Hopper plays Ben's confrontation with Jay — over the telephone — with great specificity and without raising his voice.
As Michael Mann, an executive producer of "Luck," puts it, "He focuses with great specificity.
The state used an old method, known as DQ-alpha testing, that could not identify, with great specificity, the person to whom the DNA belonged.
Although these companies require doctors to code diagnoses with great specificity, the useful information that is gathered is then discarded, whereas it might be used for epidemiologic purposes.
