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Moreover, the number or proportion of TILs is of great prognostic value in a variety of cancers17, and TILs directly targeting tumour-associated antigens could be important in the defence against tumours, which highlights potential clinical applications of immunotherapy.
Therefore, assessing EMT-CTCs and CSCs in HER2 breast cancer patients could be of great prognostic value [84].
Therefore, imaging including DWI has great prognostic value and is crucial to treatment decision making because it allows early diagnosis and an estimation of both the time of onset and the infarct-salvageable brain proportion.
Consequently, the differentiation of primary from secondary infection may be of great prognostic value for dengue patients, particularly children and the elderly, in whom a secondary dengue infection is more likely to result in DHF [4], [5].
Methods to discriminate primary and secondary DENV infection may be of great prognostic value.
However, despite the fact that dipstick proteinuria has limited diagnostic value, it is of a great prognostic value.
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Our study, however, suggests that ECS is of greater prognostic value, but that SMA plus SERPINE1 expression in combination was highly significantly associated with adverse outcomes.
The prognostic and diagnostic accuracy of SMA and SERPINE1 expression at the invasive front corresponds with observations that histological and molecular determinants at the invasive front are of greater prognostic value than the tumour centre (Bryne et al, 1992; Piffko et al, 1998; Kellermann et al, 2007; Vered et al, 2010; Kato et al, 2011).
The 3 most important biomarkers were N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and low-density lipoprotein cholesterol, where NT-proBNP and hs-cTnT had greater prognostic value than any other biomarker or clinical variable.
Furthermore, for patients with right-sided or MSI tumors TP53 mutations showed even greater prognostic value, in line with results reported by the TP53-CRC collaborative study group [55].
The use of multiple markers to identify tumours enriched for CSCs has the greatest prognostic value.
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