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As local re-recurrence is a great problem after treatment for local recurrence, the administration of high tumorcidal irradiation doses at the areas of risk follows a sound radiobiological principle.
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This is a greater problem after primarily malabsorptive procedures such as BPD-DS.
The introduction of Research and Development units in NHS Trusts may have created ownership and a business model for research, at the expense of some uniformity and cooperation between individual organisations, whose varying interpretation of the regulations led to bureaucratic delays, a process which became a greater problem after the implementation of the EU clinical trials directive in 2001.
Problem finding is an essential skill of clinical investigation, and the definition of a great problem sometimes occurs long after the solution has been observed.
"If a mass movement turns into worshipping a particular person, that's a great problem," he warned in 2012, after the campaign against national education.
I was immediately sent up to see the principal, and after that I was a great problem for everyone.
That is the great problem".
"It is a great problem.
There is no great problem.
Their great problem is operating expenses.
That's a great problem to have.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com