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The great mutations of the world are acted, or time may be too short for our designes.
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Two mutations in C. albicans, 2 patterns of mutation in C. glabrata, and 1 mutation in C. krusei had not been reported before, highlighting the great mutation diversity that could be responsible for echinocandin resistance (13 ).
As an example, we documented that 7/36 (19%) patients that were successfully treated with SP, harbored isolates with six or greater mutations.
A type of "automatic" lethal mutagenesis has been proposed for asexual populations evolving toward an optimum: ever-greater mutation rates are selected because mutator alleles disproportionately generate the favored mutants and thus hitchhike to fixation.
Although the unpaired sample had a higher than average number of mutations, it did not demonstrate the greatest mutation burden (53 putative somatic variants vs range of 3 146).
Particularly, greater mutation rates suppose a higher number of iterations, which varies between 15 to 320%.
We see that 100 mM EMS induces greater mutation rates (Figure 1) and equal or greater toxicity than lesser concentrations of EMS (Figure 2).
Though greater intelligence might be protective in innumerable ways related to lifestyle choices, greater mutation load might also lead to greater metabolic stress and reduced capacity for maintenance of brain integrity [66].
This effect will be amplified under greater mutation pressure.
Smaller mutation rates allow the evolution of complex ecological organization, while greater mutation rates inhibit it.
In our test system the variant exhibited a significantly greater mutation rate than the wild-type.
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