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However, great methodological differences exist between RCTs and observational studies, making direct comparisons difficult to interpret [ 15].
7 8 Combining data from various sources to estimate cost-effectiveness over extended time horizons, modelling studies inevitably require a large number of assumptions, 26 and comparisons to our trial-based results are hampered by the great methodological differences.
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However, large methodological differences may also be a factor here.
To conclude, although we argue that it is likely that the previously observed changes in repertoire size and composition in the great tit can be explained by methodological differences that could have led to underestimation of the repertoires, we can not totally rule out that the discrepancy in results may be due to differences among populations.
Importantly, methodological differences may be of greater importance if small bench-top analysers are used.
Briefly alluding to the methodological differences between Husserl and James, he emphasized two points where the "great masters" converged: the stream of thought and the theory of fringes.
Our modeling approach showed that differences in trial methodologies had a greater impact on NEDA outcomes than differences in patient characteristics, thus highlighting the importance of adjusting for these methodological differences.
"Any relative difference in effectiveness between S.S.R.I.'s is probably best explained by methodological differences and not by specific differences in the medications," Dr. Emslie said.
This may depend on methodological differences.
Differences could have arisen because of methodological differences.
Third, substantial methodological differences between them limit their comparability.
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