Sentence examples for great methodological challenges from inspiring English sources

Multilocus MHC genes, however, pose great methodological challenges as inter-locus sequence similarity usually prevents the development of locus-specific primers.

Investigating alcohol industry activities in the policy process involves greater methodological challenges than work on the tobacco industry, which is informed by internal industry documents made public as a result of litigation.

Although the efficacy of TNF-α inhibitors in patients who are naïve to biologic treatment has been evaluated in multiple studies [ 10- 12], evaluating the efficacy of these drugs in patients who have already experienced an inadequate response to a TNF-α inhibitor poses greater methodological challenges.

These sequences pose a great methodological and conceptual challenge for evolutionary studies since comparative approaches are not in the first instance designed to deal with unique sequences that cannot be compared to any other sequences.

A great deal of the methodological challenges of analyzing membrane proteins by HDX MS have been met, leading to a number of publications in this area and increased understanding of these proteins.

The great heterogeneity of practice organization and business models employed by CAM practitioners poses methodological challenges for defining what constitutes a "practice" for research designs that would attempt to study whole practices.

This approach pays greater recognition to the contexts, the organisational settings and accountability structures, and consequently, creates new methodological challenges of researching diverse and 'hybrid' designs and comparing healthcare systems across organisational setting.

There will be some serious methodological challenges to doing that, of course.

Resources: This paper from the US National Library of Medicine National Institutes of Health shows the methodological challenges in evaluating healthcare financing equity in data-poor contexts.

The real problem with neuroscience today isn't with the science — though plenty of methodological challenges still remain — it's with the expectations.

Methodological challenges also abound.