Cellular viability determination demonstrated greater induction of cell death by apoptosis and necrosis by Eclipse extracts in DCs.
The anxious phenotype in TTC9A−/− mice is associated with greater induction of TPH2 and 5-HTT by EB administration that positively influences the serotonergic system.
Interestingly, the heightened anxiety in TTC9A−/− mice under EB influence is consistent with a greater induction of TPH 2, and 5-HTT by EB in DRN that play key roles in emotion regulation.
This effect was concomitant with greater induction of Ag-specific CD8+ CTLs and their infiltration into the tumor sites, highlighting the importance of combined stimulation of TLR9 and 4.1BB for achieving tumor eradication.
Lopez-Souza et al. [4] showed that bronchial epithelial cells were more susceptible to HRV infection than nasal epithelial cells, which was associated with greater induction of ICAM-1 (a HRV16 receptor) following viral infection in bronchial epithelial cells.
Influenza triggers a more robust immune response than RSV, with greater induction of respiratory and systemic cytokines (Garofalo et al. 2005; Gill et al. 2008; Welliver et al. 2007).
Glycosylated gallic acid was more efficient than gallic acid or arbutin in the prevention of aging through stronger MMP-1 inhibition and a greater induction of type 1 collagen (Fig. 6a and b).
Compared with BL6 mice, 129/SVJ mice had impaired induction of antioxidant genes, generated three- to four-fold more free radicals and exhibited two-fold greater induction of profibrogenic cytokines (interleukin-4 and transforming growth factor-beta1) and fibrosis-related genes (fibronectin and tissue inhibitor of metalloproteinase-1) (all P<0.05 for 129 vs BL6).
Although ob/ob livers have significant histological liver injury and 11-fold greater serum alanine aminotransferase values than those of lean mice by 6 h post-LPS, they exhibit greater activation of AKT and Erk, more profound reductions in inhibitor kappa-B, enhanced activation of NF-kappaB, and greater induction of NF-kappaB-regulated genes.
Similarly, 10 mM NP treatment resulted in significant differences in ROS production between all sizes of NP with a 3.2-fold greater induction of ROS observed between 4 and 20-nm NPs (p = 0.001), and a 1.9-fold increase observed between 13 and 20-nm NPs (p = 0.0021).
