Sentence examples for great functional consequences from inspiring English sources

The total sum of bodily symptoms represented a heavy burden with great functional consequences.

The study also demonstrates that adolescents with CFS are severely troubled by pain and that pain has great functional consequences.

Natural selection plays critical roles in shaping CNV patterns, and dosage-sensitive CNVs might be expected to have greater functional consequences and fewer protein protein interactions than dosage-insensitive ones.

Using these tools has permitted a greater understanding of the functional consequences of mitochondrial morphology.

Detailed knowledge of these changes and their functional consequences is of great clinical utility and is already helping to determine phenotypic plasticity, histological tumour grading and overall prognosis and survival stratification in several cancer types.

Thus, although mtDNA mutations are quite common in somatic cells, the functional consequences may be greater in stem cells.

Clearly, continued efforts to more extensively identify and characterize the complex cellular changes that occur during heart failure development will allow greater insight into the mechanisms and functional consequences of altered myocardial GLUT expression.

25, 27– 33 Although wide excision is associated with a lower risk of local recurrence (up to 12%%), 25, 27, 28, 30, 34 it is necessarily associated with poorer long-term functional consequences due to greater bone loss and the limitation of joint motion due to resection reconstruction.

Adding further information about epigenetic and transcriptional regulators other than cytosine methylation plus transcriptional profiling studies will be very valuable in gaining a greater understanding of the epigenetic dysregulation and its functional consequences in IUGR.

To detect the functional consequences of MCPH1's four great-ape-specific mutations, we conducted analyses similar to that used for the human-specific sites.

Thus, miRNAs hold great potential as therapeutic targets for new drug development; however, more insights into the functional consequences and efficiency of miRNA inhibition for patient survival need to be addressed.