Delayed treatment with Tanshinone IIA markedly attenuated macrophage accumulation in the folic acid-injured kidney with a greater effect observed in the early treatment group (Fig. 6b).
Tanshinone IIA treatment markedly increased the number of F4/80+MR+ M2 subtype of macrophages in the folic acid injured kidney with a greater effect observed in the early treatment group (Fig. 7a c).
mTBI may adversely impact self-reported health, with the greatest effect observed in individuals with co-occurring mTBI/PTSD.
Glucose homeostasis improved in response to a reduced caloric diet, with a greater effect observed in the absence of surgery as compared with after RYGB.
Improvements in glycaemic control and CV risk factors with ExQW therapy were observed across the range of antihyperglycaemic agents commonly used to treat T2DM, with the greatest effect observed in patients with abnormal analyte level at baseline.
In the second trimester, total decidual cells demonstrated increased angiogenin secretion in response to T3 treatment with the greatest effect observed with 1 nM T3 compared with no T3 (1.9-fold increase, P < 0.05; Fig. 2B).
Canagliflozin 100 and 300 mg improved glycaemic control relative to placebo in patients <65 and ≥65 years of age, with a slightly greater effect observed in patients aged <65 years relative to those aged ≥65 years.
These peptides are somewhat similar to vertebrate defensins, and recombinant ABF-2 has a demonstrated broad-spectrum antimicrobial activity in vitro, with the greatest effect observed on Gram-positive bacteria (Kato et al., 2002).
In summary, the relationship between plasma HMW adiponectin and HOMA-IR is influenced by ethnicity with the greater effect observed for Aboriginals, Chinese, and South Asians compared to Europeans.
In the present study, we have demonstrated that edaravone suppresses neuronal damage in mice subjected to a CCI, with the greatest effect observed when the drug is given 3 hours after TBI.
