Older patients tend to have less physiological reserve so the same insult would be expected to have a greater deleterious effect upon prognosis [9].
At the other position (L_Q236, M_H241, and N_H224), mutation to a positively charged residue, K or R, had the greatest deleterious effect on activity, while mutation to glutamic acid had little effect (Figure 4).
This may explain why CCBs appear to have a greater deleterious effect on the ascending aorta compared to the aortic root.
90– 92 The APOE ε4 allele also has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD. 93– 95 Additionally, a large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were ε4 carriers.
Nevertheless, our functional studies are not comprehensive, and it remains possible that a further, unstudied aspect of insulin receptor function is selectively affected by the Ile119Met mutation, or that this mutation may have a greater deleterious effect in the context of the longer 'B' isoform of the insulin receptor that includes the small exon 11.
In this article we note that natural disasters are a destructive force of natural evil that will likely have even greater deleterious effects moving into the future.
Together, these data suggest that the diabetic environment, at least under the conditions of this study (i.e. severe hyperglycemia/hypoinsulinemia and sedentary behavior) has greater deleterious effects on type II compared with type I fibers.
As a result, mutations in these enhancer regions would have greater deleterious effects.
Furthermore, non-adherence resulted in greater deleterious effects in the medication management group than in the combined treatment group [ 67].
Basically, the "survival of the flattest" effect postulates that at high mutation rates a quasispecies with high reproductive capacity, but low mutational robustness can be displaced by another quasispecies with lower reproductive capacity but higher mutational robustness, that is to say, a greater insensitivity to the deleterious effect of mutations.
