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One of the great challenges of using EMR data in research is that EMR data is generally collected for the purpose of providing individual patient care and administrative purposes rather than specifically for research or surveillance [ 7, 8].
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One great challenge of using Illumina sequencing for transcriptome analysis is the short read length.
High uptake by mononuclear phagocytic system in the liver and spleen are one of the greatest challenges of using nanoparticles for tumor targeting.
Beyond accessibility and usability issues that have long been cornerstone concerns of the human factors community, is the greater challenge of using health IT in ways that better educate and empower patients to view themselves as active partners in their own medical histories, diagnostic work-ups and improved care.
Occurrence and detection of the CCR5 tropism are some of the great challenges of maraviroc use in treatment-experienced patients.
The recalcitrance of the cell wall to enzymatic hydrolysis represents one of the greatest challenges for using biomass to replace the petroleum as a feedstock for fuels and chemicals.
It has been a great challenge to use thin polymer films to enhance the efficiency of light trapping and environment coupling for organic photovoltaic (OPV) devices.
The extremely large quantum yield of the primary charge separation (close to 100%) [9] in RC presents a great challenge to use it in artificial light harvesting systems.
One of the great challenges of public services is to show our money has been used to greatest effect.
One of the great challenges in using ontologies to facilitate integrative, translational biomedical analyses is to connect ontologies that cover basic research domains, such as the GO [ 11], with medical ontologies, such as SNOMED CT [ 123] and the repository of ontologies that are within the Unified Medical Language System UMLSS) [ 124].
Isn't that one of the great challenges of leadership?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com