And then the trajectory will be converged again if we take a small change on the initial value for C, i.e. take C1 = 0.2, C2 = 0.729 and C3 = 2.520, see Figure 5 d) The multi-equilibrium property of metabolic networks is of great practical significance and difficult to be investigated biologically or theoretically.
Integrative analysis of methylomes scattered in different data recourses is a great idea, but costly and difficult to implement for experimental biologists with limited bioinformatics experience.
The second part of the citation of Goldacre "the prospects for disentangling cause and effect when it comes to publication bias are not great" is difficult to understand and, as far as I can see, does not come back in the comment.
So we cannot simply extend the methods of the Sophist and Statesman in a mechanical way to the investigation of the philosopher and other great and difficult topics.
Great and difficult crises are what produce great presidents, so one thing we know for sure: Mr. Obama's going to have his shot at greatness.
Chinquapin A. Chinquapin, you ask great and difficult questions.
But what is "War and Peace" if not a self-consciously great and difficult work?
Mightn't the system, supposedly overseen in even its smallest details by God Himself, via these representatives, actually be just a crude, man-made form, inspired by, but inaccurately addressing, even obscuring, some greater and more difficult-to-discern truth?
"It must have been obvious to any one interested in natural history that the insects met with during a walk in summer may be arranged in two great groups:... difficult to find... and... startling colours and conspicuous attitudes" The association of warning with "nauseous or dangerous" animals is identified.
Like many films about the suffering of children in wartime ("The Tin Drum," "Forbidden Games," "Au Revoir les Enfants"), "The Great Water" is difficult to watch, and just as difficult to forget.
