Those grave and mounting external pressures set up severe strains within the league and destroyed its unity of purpose.
His report also predicted grave problems for landlords whose mortgages were coming due soon, since interest rates upon refinancing would leap upward, placing severe strain on buildings' finances.
"The situation with Hib disease in Bangladesh is very grave, since drug-resistant strains are increasing, and to treat infection doctors must use expensive drugs, which are not readily available in most hospitals," said Dr. Samir Saha, a Microbiologist at Dhaka Shishu Hospital.
The hardworking Boyd Tonkin in the Independent thought, however, that White was on fine form: "However broad his compass or grave his concerns", his "strain of madcap mischief, of antic merriment, will always guarantee delight.
In March, in perhaps the gravest sign of the strains, authorities in Azerbaijan arrested 22 people they said were part of an Iranian-backed plot to kill American and Israeli diplomats and attack other targets in Baku, though the allegations are as yet unproved.
H7N9 is seen as a graver threat: That strain has infected 143 people and killed 45 since emerging in southern China in March.
While progress has been made on some fronts, the alarming spread of multidrug-resistant, extensively drug-resistant, and more recently totally-drug resistant strains is of grave concern.
Public health experts have become wary about raising alarms over new strains because the grave predictions made in 2005 and 2009 turned out to be overblown.
Whilst not all rain-splashed spores will cause infection, this high pathogen load, coupled with the "plasticity" of the Z. tritici genome, means that emergence of new fungal strains is of grave concern.
