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Maximum neuronal response was found for a stimulus diameter corresponding to the size of the CRF (indicated by the arrow in Figure 1C), and the response decreased with increasing grating size beyond the CRF.
This optimal grating size, which equates to a visual angle of ∼14°, is smaller than the calculated RF center of these cells, but would be predicted to provide good contrast between the RF center and neighboring points of visual space.
Consistent with previous reports in monkey [ 15] and mouse [ 16 18], the responses of most neurons showed first an increase with increasing size, followed by suppression as the grating size exceeded an optimal value (e.g., Figure 1B).
Also consistently with Conway and Livingstone (2006), who found few cortical neurons responding to small color patches, many of our LFPs responded to small luminance gratings but only 5% responded to small red/green gratings (40 vs. 2, for 2° grating size).
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In this part of our work, we can consider now that the grating sizes obey a distribution function D N l 0), defined in such a way that D N l 0 dl 0 gives the probability of the size of the fractal grating to be in the interval (l 0,l 0+dl 0+dl
However, the average amplitude of the LFP responses was comparable for luminance and chromatic gratings, when measured with optimal grating sizes.
First, patients with schizophrenia show decreased contrast sensitivity (i.e., need more contrast to detect a grating) across a range of grating-sizes in behavioral studies (19,20).
The pitch of both gratings was 5 µm and the grating area size was 5 mm (width) by 10 mm (height).
Roubini notes that the main problem isn't their size, grating as that may be.
We found that for grating stimuli the 'effect size' increased monotonically with the increase in the time constant (Figure 5A, bottom), indicating that information was contained predominantly in slow processes (firing rate modulations), in agreement with findings in Figure 3D.
Other studies demonstrated that gamma-band activity is strongly reduced for grating stimuli of reduced size (Gieselmann and Thiele 2008) or for 2 gratings superimposed to form a plaid (Lima et al. 2010).
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