Sentence examples for grapefruit effect from inspiring English sources

Since the grapefruit effect was first reported in the early 1990s (Bailey et al, 1991), the ingestion of grapefruit juice has been shown to enhance the systemic exposure of a number of orally administered drugs (Bailey et al, 2004).

The impact of this interaction on sales was investigated by Lee and Brown [30], who estimated a double log demand model using the frequency of major newspaper headlines on grapefruit-medicine interactions to investigate the media effect on grapefruit juice sales.

Consumers who do not take prescription medications or who take prescription medication but said the medication does not have an interaction effect with grapefruit consumption are more likely to increase consumption of grapefruit and/or grapefruit juice as age increases.

Negative health news such as the effect of grapefruit-medicine interactions bothers grapefruit consumers.

Among fruit juices, grapefruit has the strongest effect, but lime juice and orange juice made from Seville oranges similarly inhibit the CYP 3A4 enzyme.

Table 1 The effect of grapefruit on the AUC of drugs employed in cardiology Drug Approximate increase in AUC Artovastatin 150 Felodipine 225 Lovastatin 1200 Nifedipine 100 Nisoldipine 300 Nitrendipine 130 Simvastatin 1500 Verapamil 40.

The inhibitory effect of grapefruit juice on the intestinal cytochrome P450 3A4 (CYP3A4) system was discovered accidentally in 1989 during a study designed to test the effect of ethanol on a calcium-channel blocker (Bailey et al, 1989, 1991).

This finding of a reduced effect of grapefruit in women with a higher BMI is similar to the lower effect of ET on breast cancer risk in women with a higher BMI (Collaborative Group on Hormonal Factors in Breast Cancer, 1997; Schairer et al, 2000; Million Women Study Collaborators, 2003; Beral et al, 2005).

For example, you don't want to be drinking alcohol while taking some antibiotics, and particular drugs interact with chemicals in grapefruit, causing unpleasant side effects.

In this group, the inhibitory effects of grapefruit juice on CYP450 and cyt b5 were apparent but serum liver enzymes were unchanged compared with the uninfected control group.

Both the consumers who already knew the effect of grapefruit-medicine interaction and those hearing the news release for the first time indicated a lower likelihood to increase their consumption of grapefruit and/or grapefruit juice as shown in Fig. 2a.