Architectural changes were distinctive for chronic pancreatitis: pancreata exhibited atrophy of the acinar cells and were characterized by loss of zymogen granules and fragmentation of the rough endoplasmic reticulum (RER).
However, in the presence of water fragmentation of the granules was observed even at low doses when starch was irradiated before the extraction from potato [43].
Since the size of the metal catalyst particle determines the width of the nanotube, we have investigated the notion of introducing a dispersing agent into the catalyst formulation that facilitates fragmentation and prevents sintering of the granules during the reduction step.
Susceptibility to fragmentation was related to the mechanical properties of starch granules associated with their architecture and botanical origin.
In group 2, the smaller and structurally altered mitochondrial, the thinned and fragmentation of myogenic fibrils, decrease of content in glycogen granules in the swollen myocardial cell were found, but in group 1 were no significantly pathological future.
The partial fragmentation is advantageous as the radicals formed in inner part of the granules after fragmentation can also take part in the network formation.
It was revealed that the cold deformation introduced during the mechanical fragmentation of chips and chemical microsegregation inherited from a rapid solidification by granules, represent key features which control the generation of equiaxed structures during the very initial stages of melting.
Mitochondrial damage was assessed using FLAMENG grading system [ 17]: 0 = normal matrix granules without visible damage; 1 = loss of matrix granules and light clearing of matrix; 2 = moderate clearing of matrix, moderate swelling, and partial fragmentation of cristae; 3 = severe clearing, severe swelling, and loss of cristae; and 4 = amorphous dense granules.
The presence of these holes on the shell is consistent with previous studies demonstrating that digestion of normal granules starts with surface pores and proceeds through deeper hydrolysis in channels [ 49- 52], followed by fragmentation [ 48].
