A kidney biopsy was performed, and immunoflourescence findings demonstrated granular deposits of IgA in a mesangial pattern confirming the diagnosis of IgA nephropathy.
Both of these models show characteristic ultrastructural findings, namely granular osmiophilic deposits (GRODs) in the Cln1-/ and curvilinear as well as fingerprint profiles in the Cln5-/ mice [ 5, 6].
The finding "eosinophilic granular material with particles" was no longer visible after the post-exposure period.
While a microtubular or fingerprint ultrastructure on EM is very specific for CG-GN, a finding of granular deposits as seen in our case does not prove or exclude this disorder [ 10, 12].
Intraoperative findings included purple granular lesions that were spread diffusely along the surface of the appendix.
Simple calculations based on the Janssen model for granular material related to our findings on bodyform and locomotor behaviour render a local decompaction of the sand surrounding the moving sandfish very likely.
Immunofluorescence microscopy findings showed strong granular mesangial glomerular staining with IgG (4+) and C3 (3+).
Based on the experimental finding that the granular area was not seen in short life regime at high stress levels, but observed in long life regime at low stress levels, the subsurface crack initiation was estimated by examining whether the granular area was present or not after testing.
Along with our previous finding that the granular species also turned into amyloid fibrils instantaneously in the presence of hexane [57], the structural distortion of the preformed oligomeric species is demonstrated to be a prerequisite for the amyloid fibril formation.
Several studies have reported on the FAF findings such as the granular pattern in the eyes with a PIOL [4, 5].
Intraoperative findings included purple-colored, granular lesions that were raspberry-like in appearance and were spread diffusely along the surface of the appendix (Fig. 2a).
