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Cases of torture and wrongful imprisonment are increasingly reported in the controlled Chinese press, a sign that the central leadership feels it must acknowledge and attack a problem that for most Chinese is a more immediate human rights concern than any grand issue of democracy.
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They almost never mention the grand issues of the day; nearly all have to do with paying back favors for old family friends in an old-boy network.
The world would be better off, the critics say, if economists returned to the sort of grand issues that had occupied John Maynard Keynes and Milton Friedman.
All the collaborations at the Aldrich offer plenty of opportunities for ruminating on grand issues: millennial malaise, the implications of a mass-cultural zombie obsession or the passing of an old tree.
The government has also awarded contracts to an advertising company in which his family holds a stake.Mr Thaksin insists that he does not concern himself with petty matters like advertising budgets, and cannot avoid grand issues like telecoms regulation.
Many young people marked their identities -- not just for the moment but for the rest of their lives -- by the stands they took on the grand issues of poverty, war, free speech and human rights.
Beneath the grand issues hanging over Iraq, like the coming national elections or the continuing violence, the day-to-day lives of most Iraqis turn on more quotidian concerns: the lack of electricity; the pervasive corruption; and a housing shortage that forces two, three, even four families to live under the same roof.
If the problem persists, your upset stomach is just a symptom of a grander issue.
The same is true of some grander issues.
For the New York Mets, however, there are grander issues at hand.
Answers to questions that FOP poses will also address grander issues of how the body first creates its shape and then knows where to stop, how tissues decide to become what they are, and why they do not turn into something else" (Maeder, 1998).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com