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Mice (six per group) received either raltegravir (3.28 mg per 20 gram mouse) or maraviroc (1.23 mg per 20 gram mouse) by oral gavage daily.
Half of the mice were surgically castrated: mice were anesthetized using Ketamine/2% Xylazine at 5.7∶1 ratio (0.1 ml per 25 30 gram mouse).
Two month-old mice received intraperitoneal injections at 100 µg TM per gram mouse weight once a day for 10 consecutive days and were analysed 3 months later.
We used a PSA concentration in our in vivo studies that exceeds the amount of PSA found in human blood: we injected 50 μg of protein per animal, which is equivalent to 25 50 μg/mL, given the blood volume of a 18 25 gram mouse is 1 2 mL [ 52].
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At the expense of injections on a daily basis of as much as 2 ml of blood (1 ml huRBC pellet) IP in 25 gram mice, and using a mouse adapted strain of P. falciparum, improved results as compared to NOD/SCID/β2m mice [11] were obtained.
Ninety-six 25–30 gram mice were inoculated intracisternally with serotype 3 Streptococcus pneumoniae modified by the integration of a luminescent lux operon.
Thus while trying to reclassify species in a family of South American rodents called Octodontoidea, evolutionary biologist Milton Gallardo of the Universidad Austral de Chile was surprised to find in 1990 that a 100-gram mouse, called Tympanoctomys barrerae, had 51 pairs of chromosomes.
The pilot studies used ten male skeletally mature Black CD57 (24 26 grams) mice divided into two groups to test for the feasibility of gene array in bone organs.
When tumor diameters were more than 5 mm after 25 days, the 16 tumor-bearing nude mice were randomly divided into two groups: group 1 consisted of eight tumor-bearing nude mice that were intratumorally injected with 0.2 ml normal saline (NS) containing 8 μg cisplatin per gram of mouse body weight for three consecutive days.
CCl4 was diluted in mineral oil (Sigma-Aldrich) and administered at a dose of 1 µL per gram of mouse.
Subsequently, the yeast suspension was introduced into the left tail vein, delivering a total of 5×104 yeast cells per gram of mouse.
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