Else, add a new Q-gram key and its position in the corresponding bucket in HTMQ.
Doripenem, a broad-spectrum carbapenem, provides coverage of key gram-negative and -positive aerobes and anaerobes encountered in cIAI.
The unimodal susceptibility pattern is indicative of excellent and near complete activity against key Gram-positive pathogens including multiply resistant strains, but surveillance for emerging resistances (rare) and the performance of routine susceptibility tests to guide patient therapy seems prudent.
National surveillance of antimicrobial resistance shows no significant increases in resistance to key Gram-negative organisms and reduced resistance to third generation cephalosporins in E. coli.
The Antimicrobial Availability Task Force, created by the Infectious Diseases Society of America, identified six pathogenic micro-organisms, including three key Gram-negative pathogens, as being significant concerns.
In summary, A. baumannii, ESBL-producing Enterobacteriaceae, and P. aeruginosa are key Gram-negative pathogens that are involved in serious nosocomial infections.
We now face the challenge of emerging carbapenem resistance, largely mediated by the efficient spread of carbapenemases in key Gram-negative pathogens [ 15, 16].
The clinical studies highlighted in the preceding sections illustrate that patients infected with resistant strains of key Gram-negative pathogens have increased mortality, longer hospital stays, and higher hospital costs than those infected by susceptible strains.
In healthy adult volunteers, telavancin at 7.5 15 mg/kg/day administered as an i.v. infusion displayed linear pharmacokinetics, with an elimination half-life (t½) averaging 7 h and trough plasma concentrations exceeding the minimum concentration required to inhibit the growth of 90%% of organisms for key Gram-positive pathogens [ 7, 8].
From the first total syntheses by the groups of Evans and Kishi in 1997 and 1998 which delivered milligram quantities of spongistatins/altohyrtins, further intensive studies have led to new pathways with practical solution to provide gram scale amounts of key intermediates.
If the Q-Gram exists in the key field, append the new position in the bucket HTMQ[ Q-gram].
