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Gradually, resistant bacteria predominate, making the antibiotic less and less effective.
A second treatment at day four showed that RSV was not able to further inhibit cell growth, which restarted from day 6 for PROb and more progressively for SW620 cells, indicating that these cell lines became gradually resistant.
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Thus, tumor cells can gradually become resistant to chemotherapy drugs.
However, those patients with distant metastases exhibit disease progression within 12 to 18 months on average and gradually manifest resistant to endocrine therapies thereafter [ 1].
Soleus gradually became fatigue resistant, whereas, after axotomy, soleus remained fatigueable up to adulthood.
The group of articles on S. pneumoniae models published by Temime et al. (15, 32, 33) and Opatowski et al. (35, 36) presents one example of strain conversion, in which a sensitive strain gradually becomes more resistant as a result of repeated point mutations.
Tolerance is a long process during which parasites acquire several genetic changes making them gradually more tolerant of CQ, whereas a resistant parasite is unaffected by drug exposure.[15].
In one case, the endemic strain evolved gradually from a moderate resistant to a multi-drug resistant phenotype [ 12].
In the first phase, viruses carrying various combinations of multiple-drug-resistant (MDR) mutations predominated with each mutation persisting in relatively stable proportions while the overall number of resistant viruses gradually increased.
In addition, complex chemical reactions within the loose tephra within the island have gradually formed highly erosion resistant tuff material, in a process known as palagonitization.
As a result, while infections caused by resistant microorganisms gradually increase, antimicrobial options used for treating them rapidly diminish [ 6, 7].
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