Exact(18)
Although the early time point represents maximal transcriptional activation for some of the up-regulated genes, most of the transcripts continued to accumulate at the later time point, so that in addition to clusters of induced and repressed genes, there is a large cluster of "gradually induced" reciliation genes (Table 2).
In parallel, expression of Δ- pyrroline-5-carboxylate synthetase 1 (P5CS1), a well-known salt stress-induced gene involved in proline synthesis [ 38], was shown to be gradually induced, thus validating our experimental conditions (figure 2G).
Prostratin slightly and gradually induced histone H4 acetylation starting at the 20 min treatment up to the 2 h treatment.
Conversely, few pro-apoptotic genes are expressed in ES cells (day 0; most boxes appear in green), but many are gradually induced during the differentiation process showing the exact opposite pattern from the genes involved in cell proliferation (Figure 7).
Intriguingly, we here showed that the proteasome activity was gradually induced rather than impaired in the spinal cord of SOD1H46R-expressing mice as the disease progressed, and that loss of ALS2 further enhanced their activation.
Many genes for cytosolic antioxidant enzymes, such as Apx2, are gradually induced to very high levels.
Similar(42)
Dr. Eren feels that the U.N.'s most important function is not in effecting definite changes, but in gradually inducing humane reforms and changes in attitude.
The average noise during waking hours is at or above the level that gradually induces deafness, whereas the average speed of motor traffic, in spite of the audacity and acuity of the drivers, is utterly slow.
The wrinkles gradually induce a reduction in axial rigidity eventually leading to a limit load instability followed by collapse.
With a continuing increase in strain, the necking deformation gradually induces the nanowire to become a two-atom-wide chain in the middle region as shown in Figure 4e,f.
The ability to gradually induce a reversible switch between SET and RESET states, integrated with several superior transition properties such as fast switching speed, low energy consumption, and long retention, has made phase-change-based devices a leading candidate to emulate the biological synaptic events.
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