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HFD-induced obesity may gradually impair the well maintained balance between adipocyte and osteoblast differentiation in bone marrow, causing a shift that favors adipogenesis while suppressing osteogenesis.
In ageing societies growing numbers of older adults will develop diseases that gradually impair their decision-making capacity [ 1, 2].
The abnormalities in these proteins cause the appearance and growth of kidney cysts that gradually impair renal function [ 1].
ISRCTN89993391 As the population ages worldwide, growing numbers of older adults develop Alzheimer's disease and related disorders that gradually impair their decision-making capacity [ 1].
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Vehicle-treated G93A mice began to show a decline in motor performance around the age of 100 days that continued to be gradually impaired thereafter; the mice were unable to perform the test around the age of 130 days.
The vehicle-treated H46R rats began to show a decline in motor performance around the age of 170 days that continued to be gradually impaired thereafter; the mice were unable to perform the test around the age of 220 days.
Thereby the passage of K+ would be gradually impaired and lead to a reduction and finally inhibition of current [ 29].
However, mild to moderate anemia occurs or persists in some individuals on long-term therapy and gradually impairs the individual's functional status [ 2, 8, 21].
Since RAD51 foci are completely absent upon PARP inhibition in cells with homozygous loss of BRCA1, but not affected in heterozygous mutation carriers (Farmer et al., 2005), these ex vivo data suggest that the accumulation of indels in MMR-deficient tumors gradually impairs the DSBR by HR pathway to a level that is intermediate to that of cells heterozygous- and homozygous-deficient for BRCA1.
Abnormal FMD was gradually further impaired in the patients without SMI, with SMI but no CAD, and with both SMI and CAD.
However by global convention loans are not marked to market, but carried at cost and impaired gradually.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com