Spaniel ancestors have been known since the 14th century, gradually differentiated into land, water, and toy breeds.
The existing species of Pinnipedia show some gradational forms between the most aquatic species, and those (as the Otarice) which more nearly resemble the terrestrial Carnivores, and upon the supposition that the former have been gradually differentiated from the latter, it might be hoped that paleontology would have revealed some further stages in the series of modifications.
Studies of developmental biology have demonstrated that the zygote is totipotent and can gradually differentiate into all tissues and organs of the human body, that is composed by more than 200 types of specialized cells.
The sites of atherosclerotic plaque development in the arterial wall are characterized by cholesterol accumulation and infiltration of peripheral blood monocytes, which gradually differentiate into macrophages.
M. truncatula possesses green embryos, and during seed development, the chloroplasts gradually differentiate into storage plastids [ 56].
Although the CEPs would gradually differentiate into CECs, the next course of chemotherapy might destroy some cells that were in transition before they could fully differentiate into CECs.
Interestingly, hESCs grown in the presence of PD0332991 gradually differentiated as shown by the decrease in pluripotency marker expression and by the increase in meso/endoderm markers.
After stem cell division, the daughter cells migrate along the crypt-villus axis as they gradually differentiate into different types of epithelial cells.
In brief, LS + regions had small carcinoma cells confined to the stroma at the gland-neck level that gradually differentiated to signet ring cells in the superficial (and deep) lamina propria.
After AAF intoxication, regeneration is known to proceed from the division of oval cells that proliferate and gradually differentiate into hepatocytes [1], [24], [25].
