Sentence examples for gradual dose escalation from inspiring English sources
Adverse effects are generally temporary and can be minimised by gradual dose escalation, as planned in this study.
Gradual dose escalation of ExBID has been shown to reduce the proportion of patients experiencing exenatide-related nausea and vomiting [ 25].
Gradual dose escalation at initiation of exenatide therapy is recommended, having been shown to be effective at mitigating nausea and vomiting with no loss of glucoregulatory activity [ 7].
One study 84 showed that gradual dose escalation successfully reduced the proportion of patients experiencing dose-limiting nausea and vomiting without compromising glycemic control.
Holthuis et al (1985) performed combination chemotherapy with cyclophosph-amide, adriamycin and etoposide for haemodialysis patients with small-cell lung cancer, and a gradual dose escalation of etoposide showed that 127 mg m−2 of the agent was feasible.
However, previous studies have demonstrated for native GLP-1 and for other drugs in this class that gradual dose escalation may help to mitigate the recognized GI side effects through induction of drug tolerance [ 10].
Current best practices suggest gradual dose-escalation of urate lowering therapy and serial serum urate (sUA) measurement to achieve sUA < 6.0 mg/dl.
Gradual dose re-escalations to 37.5 mg, alternating 50 and 37.5 mg and 50 mg sunitinib daily doses (all 4/2 schedule) were subsequently introduced in the fourth, fifth and sixth treatment cycles, respectively, without any significant toxicity issues.
There is evidence with both exenatide (23) and liraglutide (15) that gradual and progressive dose escalation can reduce the incidence of nausea (these adverse events).
Because the initial experience with this approach resulted in an unacceptably high incidence of facial numbness, a gradual dose and volume de-escalation was performed over several years.
Between September and October 2010, an agreement was obtained from the patient and his family for dose escalation, and gradual titration up to 15 mg/d was achieved by October 2010.
