Table 1 provides details of the grading scheme, and cross-references our groupings with the AREDS and Rotterdam grades, where visual impairment plays an additional role in classification.
Our findings are similar to the experience of the Nottingham group, who used a similar design and radiological grading scheme and found a 45% rate of malignancy (Burrell et al, 1996).
The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system.
Tests and grading schemes were developed by CHY and SG and reviewed and revised by AS (content experts) before study launch.
These grading schemes are designed and validated for direct laryngoscopy only; however, this measure is used throughout all of the studies, as no other alternate scheme exists.
Tumours were histologically graded according to the Nottingham modification of the Bloom and Richardson histological grading scheme (Bloom and Richardson, 1957; Elston, 1987).
The two best established and most widely used grading schemes are the 'National Cancer Institute' and the 'Fédération Nationale des Centres de Lutte Contre le Cancer' systems.
The aims of this study were to evaluate the results of femoral varus osteotomy for the treatment of Perthes disease according to various classification and grading schemes, as well as to compare the results to those obtained using other methods of treatment reported in the literature.
Using the Tabar 5-tier grading scheme (Tabar and Dean, 1983), lesions are assigned to one of five radiologic grades: grade 1, normal; grade 2, benign; grade 3, indeterminate/equivocal, grade 4, suspicious for malignancy and grade 5, radiologically malignant.
Leviton and Nelson provide an overview of qualitative and quantitative grading schemes [ 27].
