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Despite the limitations, our study has several strengths, including the use of trained experienced graders and a standardized grading protocol with documented reproducibility.
Retinal vascular fractal dimension (Df) and other quantitative retinal vascular parameters (branching angle, tortuosity, and caliber) were measured based on a standardized grading protocol from photographs of the retinal fundus using a computer-assisted program.
To describe the imaging standards, grading protocol and baseline characteristics of polypoidal choroidal vasculopathy (PCV) from the EVEREST study.
Consensus readings were performed by two certified OCT readers of each reading center using their grading protocol.
Blinded to the experiment, an observer analyzed the histological sections and graded them by using the recently established histology grading protocol [ 24].
Interestingly, the three classes of our grading protocol were similar to the three classes of the mechanism, Glasgow coma scale, age, and arterial pressure (MGAP) score developed by French EMS [ 15].
Similar(51)
However, the comparability and reproducibility of OCT gradings of readers from independent RCs using different grading protocols have not been evaluated to our knowledge.
The purpose of this study was to develop image grading protocols suited to ultra-widefield imaging (UWFI) in an aged population.
RCs developed individual grading protocols, software tools and measuring devices.
Both RCs followed their own grading protocols for the selected parameters.
These methods may provide the reference for standardised imaging and grading protocols for PCV in future multicentre studies.
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