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Grading of changes of the log2-ratios is as follows: 0, unchanged with log2-ratio smaller 0.5; +, log2-ratio between 0.5 and 1; ++, log2-ratio between 1 and 2.5; +++, log2-ratio larger than 2.5.
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Furthermore, consideration of the organ reaction and grade of changes were examined by calculating organ index (OX) of each organ separately.
Table 1 shows numbers of individuals in each category and their subdivision according to grade of changes.
We do not know what grade of changes produces functional effects and whether there is a dose-effect or a threshold relation between the severity of changes and the risk of functional decline.
When we compared the severe with the mild grades of changes and adjusted for confounders by Cox analysis (table 7), the hazard of transition to disability or death was more than twofold higher for the severe Fazekas group.
For hard rocks, the lowest grade of change in shape is allowed and it is vice versa for soft rocks.
*Total number of limbs in the group Grade of change: 0, negative; 1, very slight; 2, slight; 3, moderate; 4, severe.
Microscopic grading of the changes in the colon revealed decreased inflammatory activity in mice treated with ASA (summarized scores are shown in Figure 3(c)).
Furthermore, the grading of the changes in the individual arteries was considered to be linear, although this is not the case.
At present, several different radiographic classification systems are used but the Kellgren-Lawrence (K-L) scale for grading of radiological changes has been most widely used in the past [ 17].
Intra-articular SUVmax and joint-SUVmean of F-FDG on PET/CT were measured and calculated at knees for determination of metabolic changes of the joints in association with aging, grade of bony changes, and presence of clinico-laboratory and radiological knee OA, as defined by the American College of Rheumatology (ACR).
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