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To calculate the average lens density (ALD) and nuclear lens density (NLD) using Scheimpflug images and to determine their correlation with logarithmic minimal angle resolution (logMAR) best-corrected visual acuity (BCVA), contrast sensitivity (CS), and lens grading based on the Lens Opacities Classification System (LOCS) III.
PURPOSE: To calculate the average lens density (ALD) and nuclear lens density (NLD) using Scheimpflug images and to determine their correlation with logarithmic minimal angle resolution (logMAR) best-corrected visual acuity (BCVA), contrast sensitivity (CS), and lens grading based on the Lens Opacities Classification System (LOCS) III.
2, 3 The World Health Organization (WHO) classifies astrocytomas based on histologic type, 2, 4 with grading based on the most malignant region of the tumors.
Medical management is aimed at correctly identifying the irAE, grading based on the National Cancer Institute common toxicity criteria of AEs, and initiating early treatment with supportive care or immunosuppressive medications, typically corticosteroids.
As well as determining tumour stage and nodal status, tumours were assessed using the WHO, Lauren, Mulligan and Ming classifications, in addition to grading based on the degree of differentiation.
Baseline assessment included demographic and medical questionnaire, clinical history from the participant and where available an informant detailing any cognitive symptoms, grading of lens opacities with the lens opacity classification system III (LOCSIII) 13 and age-related macular disease (AMD) grading based on the guidelines of the international classification and grading system.
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