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Toxicity grades were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (v3.0).
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For each qualitative variable (virulence genotyping), comparison between ulcer grades was assessed using Fisher's exact test.
The stability of these genes across different tissues and tumor grades was assessed using geNorm algorithm [ 24].
The correlation between HHGS score and OARSI-COH grades was assessed using a Spearman's rank test.
Difference in prevalence across the grades was assessed using a Chi square test for linear trend in proportion without adjusting for multiple testing because the tests were done for exploratory purposes for the subsequent multivariate analyses.
The percentage contribution of each parameter on grey relational grade was assessed using ANOVA.
13 Histological grade was assessed using the French Federation of Cancer Centers FNCLCCC) grading system.
Tumour grade was assessed using the Nottingham method [ 15].
Tumor grade was assessed using the nuclear grading scheme as outlined by Edmondson and Steiner.
The histological grade was assessed using the Nottingham grading system [ 13].
Tumour grade was assessed using the International Federation of Gynecology and Obstetrics (FIGO) system and by nuclear grading.
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