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Americans have given up at more than twice that rate, thanks largely to indoor-smoking bans and repeated tax hikes.Like cigarettes, the bonds come in varying grades of toxicity.
We focus here on the biological toxicity concerning the liver, kidney, and bone marrow functions using OMS grades of toxicity, evaluated on blood tests at D7, D14, and D28.
Vincristine was completely omitted for higher grades of toxicity.
The highest grades of toxicity observed during CRT and after CRT were recorded.
Comparisons of categorical date (e.g. grades of toxicity) will be done by the chi-square test.
The distribution of all grades of toxicity was similar in the two groups, except for leukopenia, which was higher in DD/DI arm (p = 0.016).
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However, this design treats the toxicity response as a binary indicator of dose limiting toxicity (DLT) and does not account for the number and specific grades of toxicities experienced by patients during the trial.
The baseline was defined as the date of commencement of chemotherapy and the events were the grades of toxicities encountered.
Figure 4a provides the distribution of all grades of toxicities considered at least possibly related to the drug administration.
Patients who were identified as having treatment modified or discontinued because of toxicity were then further examined to identify the grades of toxicities during their treatment course.
Dose modifications of oxaliplatin or 5-FU were made for hematologic, gastrointestinal, or neurologic toxic effects on the basis of the most severe grade of toxicity that had occurred during the previous cycle.
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