The stage and grade of primary breast tumors were as follows: 3 cases at stage I of disease, 12 at stage II, 7 at stage III, and 1 at stage IV.
The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI).
A schematic illustration in Figure 6 summarizes our extensive findings, portraying for the first time the potential functional role of UCP2 within a contextual framework of histological grade of primary breast cancer.
Our comprehensive analysis, focused on mitochondrial function in the context of histological grade of primary breast cancer, has revealed that both endogenous and experimentally induced UCP2 serve to reduce [Ca2+]m and ROS levels while maintaining mitochondrial membrane potential (Δ ψm).
We previously reported that high SUV levels (4.0 or more) in primary breast tumors significantly correlated with higher nuclear grades and poorer prognoses of primary breast tumors [ 9].
Histologic analysis of primary breast carcinoma features included histologic type, histologic grade, LVI and BVI.
All but one of the series of primary breast cancers and all brain metastases were grade 3 invasive ductal carcinomas-no specific type (IDC-NST) [ 29].
Such characteristics of primary breast cancer as small tumor size, node negativity, low grade and early stage may also be associated with better outcome after liver metastasectomy [9, 13, 14].
Analysis has shown a relative interdependence between the steroid receptor status of primary breast cancer and other prognostic variables such as histological grade, lymphocytic infiltration and tumour elastosis.
Eight different prognostic factors, including menopausal status, tumour size, grading, lymphatic invasion, desmoplasia, necrosis, c-erbB-2 and laminin receptor expression, were evaluated retrospectively on a large series of primary breast carcinoma patients.
