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The difference in the associations between antioxidants and survival of patients with different glioma grades may be explained by the specific tumor biology, differences in the interaction between the treatment and antioxidants, or by chance.
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These poor results for Patient safety grade may be explained by the top-down initiation of the change process, and hence the lack of support at the unit level.
The more frequent normally graded sediments may be explained by deeper flooding from the tsunami.
The 30% with a positive HPV test but with no confirmatory high-grade lesion may be explained by the observation that colposcopic biopsy misses 26 42% of prevalent CIN2+ (depending on the severity of the lesion and the number of biopsies taken) (Marc Stoler, Eurogin 2010), with the main problem being the subjectivity in determining the location of the lesion [16].
This may also have reduced our power to detect the effect of grade on recurrence risk, and the high proportion of HER-2/nue positivity among grade 2 lesions may be explained on the same basis.
The interrelations between BMI, depressed mood and knee pain may be explained by low-grade inflammation and dysregulation of the hypothalamic-pituitary-adrenal axis (HPA axis).
This discrepancy may be explained by the fact that poor-grade patients were under-represented in the Cooperative Study.
In contrast, the inverse association with EGFR amplification may be explained by its prevalence in WHO grade II tumors.
On the other hand, the lack of effect of exercise on IL-6 may be explained by the origin of the low-grade inflammation.
The severity of Child-Pugh grading did not significantly predict death in our study; this finding may be explained that the major causes of death in our cirrhotic patients were not liver failure.
The ethnic difference in grade ≥3 NSAEs between Asian and Western patients observed in our analysis may be explained by the different frequencies of polymorphisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com