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There was no significant difference in grades between the two groups (Table 2).
Data from patients with laryngeal views differing by two or more consecutive grades between the two laryngoscopies eg grade I and grade II b ) were excluded from the subsequent statistical analysis (see Discussion).
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Because grading system adopted in the external dataset was distinct from that in the discovery set [21] [23], we could not make a simple comparison of malignant grade between the two datasets.
Immunostainings for Ki67 and quantification of positive cells showed no difference in tumors of the same grade between the two groups (data not shown) further supporting the in vitro data that HRG did not seem to have a direct effect on glial cell proliferation.
There was no difference in the distribution of histological grade between the two groups (P = 1).
Reliability in assessing kappa levels for CONSORT grading between the two reviewers measured 0.89.
The concordance in the assessment of tumor grade between the two pathologists was moderate (kappa 0.53, 95% CI 0.49 0.59).
However a more sensitive test comparing the worst recorded mucositis grade between the two arms was statistically significant (P = 0.009).
Liver biopsy assessment did not detect any differences in steatosis grade between the two treatment arms (Table 4).
Comparison of RACK1 grading between the two groups resulted in a statistical difference (1 ± 0 vs. 0.2 ± 0.36 respectively; P < 0.001).
No differences were found in patient age, sex, meningioma progression, or pathological grade between the two skull base bone-invasive meningioma groups and their control counterparts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com