Grading assessments (after initial grading) are assumed to be 100% accurate, as they are checked multiple times by other graders.
Treatment of high-grade SIL was assumed to include loop electrosurgical excision procedure (LEEP), and subsequent reexamination and Pap tests (15, 16 ).
According to previously reported experimental data, the alpha/beta value of grade 3 gliomas was assumed to be 14 Gy [ 11- 13].
Patients with any grade (maximum AE grade) were included; it was assumed that palliative treatment was taken, even if AEs were milder.
Because the actual effect is to exclude all Flight Grade 66 events, it was assumed that the effect was global, and affected the readout QE globally, and was not applicable to an adjustment to the QE Uniformity calibration.
For these scenarios the sensitivity of testing for at least high grade squamous intraepithelial lesions was assumed to be 3%, 15%, and 38%, respectively.
In these controls, the prevalence of presumed advanced fibrosis (FT > 0.48, equivalent to METAVIR stage F2F3F4) or advanced activity (AT > 0.52, equivalent to METAVIR grade A2A3) [ 21] was assumed to be lower than 5% in both groups.
2nd grade medical students knowledge was assumed to correspond to a high recall accuracy about the Golgi, and was expected to represent the mean the recall accuracy of a student sample after the research intervention.
Based on results from a pilot study of 24 Grade 7 children, it was assumed that 60% of children, on average, would provide the correct response to a health question before the intervention.
Therefore, the proportion of grades 1 2 to 3 4 was assumed to be 50 50.
