Sentence examples for grade precursor from inspiring English sources

These tumors likely represent primary GBM based on a relatively short duration of symptoms in patients with available history and lack of a documented lower grade precursor per established criteria [36].

The majority of acute HPV infections induce low grade precursor lesions that are cleared spontaneously after several months in more than 90% of cases, and less than 10% eventually progress to high grade lesions or invasive cancer.

Glioblastoma multiforme (GBM) represents the highest grade (WHO grade IV) within the prevailing astrocytic category of tumors, and present either as a de novo neoplasm (primary GBM) or as the endpoint of tumor progression from a lower grade precursor (secondary GBM).

This demonstrates that when searching for diagnostic biomarkers able to distinguish low from high grade precursor lesions, it is reasonable to exclude the cancers from the analyses to avoid potential skewing of cut-offs, it appears that virtually all the cancers may be detected regardless of the best final cut-offs chosen to detect the CIN2/3.

For example, pGBM demonstrate mutation of the PTEN gene and frequent loss of heterozygosity on chromosome 10q (inclusive of the PTEN gene locus), amplification of EGFR, deletions of CDKN2A (p16), while sGBM and their lower grade precursor lesions have frequent mutations of the TP53 gene and the IDH1 gene [ 3- 7].

Some samples appeared to fully retain and maintain CIMP in their higher grade lesions whatever level CIMP hypermethylation was observed within the lower grade precursor lesions, presumably due to the importance of this high level of general hypermethylation to the tumors survival.

We demonstrated that these samples had the expected high levels of IDH1 mutation and that in the lower grade precursors this nearly uniformly resulted in a CIMP phenotype.

In this report we have used the latest Illumina Infinium HumanMethylation450 BeadChips to assess the genome-wide methylation of 20 secondary glioblastomas and their matching lower grade precursors.

More recently, Appin et al. [ 4] reported that GBM-Os tend to arise in younger patients, more frequently originate from lower grade precursors and are associated with longer survival.

High-grade precursor lesions and carcinomas that contained hyper- as well as hypomethylated L1 DNA yielded PCR signals with both primers.

ODs may also present as anaplastic tumors that lack a clinically manifest low-grade precursor lesion.