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Dose modifications of oxaliplatin or 5-FU were made for hematologic, gastrointestinal, or neurologic toxic effects based on the most severe grade of toxicity that had occurred during the previous cycle.
Dose modifications of oxaliplatin or 5-FU were made for hematologic, gastrointestinal, or neurologic toxic effects on the basis of the most severe grade of toxicity that had occurred during the previous cycle.
As shown in Figure 3B,C, the blood-based and cranium-based methods do not separate patients with and without any grade of toxicity.
The SBG 2000-1 is the first randomised trial designed to compare individually dosed chemotherapy without G-CSF support based on grade of toxicity to standard-dosed chemotherapy based on body surface area (BSA).
WHO grade of toxicity was recorded at each cycle.
Dose adjustments were made based on the worst grade of toxicity encountered during the previous cycle.
Similar(27)
During CRT, the chemotherapy doses were modified based on the worse grade of toxicities.
The median grade of toxicities with TKI was 2.3, and with sirolimus 1.7.
Worst grade of toxicities and maximum tumor shrinkage over the duration of treatment were used for the analysis.
There was no correlation between Cmax or AUC0 ∞ and the occurrence or grade of toxicities (Table 1).
Table 3 details the highest grade of toxicities reported for each breast at any time following APBI.
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