We performed selection of the minimal number of probes which achieved the highest possible sensitivity (Histologic Grade HG3 patients correctly identified) and an acceptable level of specificity (HG1 patients correctly classified), in order to have accurate grade assignments.
I would say a high degree of specificity.
Second, this study has classified retina transcripts into different grades of retinal specificities that will help us define them as common, neural specific or retinal specific genes.
Several instruments exist, for example, the Franco-Italian glossary (Sinistrero et al, 1993), the RTOG/EORTC late radiation morbidity scoring schema (Rubin et al, 1995), the SOMA-LENT system (Mornex et al, 1997) and CTCAE (Trotti et al, 2003), but many of these combine multiple signs and symptoms into a single grade leading to loss of specificity.
Thyroid transcription factor-1 and napsin A both show an impressing sensitivity almost independent of grading, but with a noteworthy lack of specificity for adenocarcinomas of the lung.
Hence, although low ADC values are frequently seen in high-grade neoplasms, the specificity of this method for grading gliomas remains low.
For the detection of histological grade ≥1B sensitivity, specificity, PPV, and NPV were 63 %, 70%, 244 %, and 93%%, respectively (Table 2).
The lack of specificity angered several council members.
Sondheim's art is a question of specificity.
