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This discrepancy is explained by the tendency to overestimate the grade of side effects in clinical routine and the more critical approach how a patients sequelae should be scored within a study.
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Unlike the Bangladesh study (4 ), the Karakalpakstan study used moxifloxacin instead of gatifloxacin and included scheduled electrocardiograms (ECGs) and graded assessments of side effects to monitor for safety, including cardiac toxicity.
The main study parameters are adherence, the plasma concentration of erlotinib and the number and grade of side-effects.
The observation of an inverse correlation of disease control with treatment tolerance was confirmed when side effects were analysed according to severity: in patients experiencing minor toxicities (WHO grade ⩽2; n=284), the median number of side effects was 3 (range, 0 10) in case of treatment efficacy, and 2 (range, 0 7) in nonresponders.
The summary of side effects in grade 3 or 4 is shown in Table 3.
The majority of side effects reported were grade 1 2.
There's lots of side effects".
But others warn of side effects.
The incidence of side effects is low.
Be aware of side effects.
The time at which the maximal grade of late side effects was observed, that is, before 2 years had elapsed, was retained for analysis (RTOG-1).
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