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Association between genotype and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration in the total population was assessed by Chi-square analysis.
Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism.
The same authors performed an analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration: a significant correlation for MAOA uVNTR polymorphism was found.
In this way, the ABL/BCRs could play an important role in the grade of response to kinase inhibitors that target BCR/ABL.
As previously shown by our group (Fiorentino et al, 2001), the grade of response of breast cancer to primary chemotherapy, showed by mammography and echography (data not shown), was less marked than the grade of response seen at clinical examination.
On multivariate analysis, increasing pathological grade of response, negative oestrogen receptor status and absence of histologically detectable residual disease in axillary nodes following chemotherapy were independent predictors of improved overall survival in this group of patients.
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The 169 discrepancies regarding grading of response in the breast are detailed in Table 1.
In all patients after the sixth cycle the response to treatment was assessed with an MRI and a PET scan to define three grades of response: complete, partial, or stable disease.
In patients who did not achieve pCR in this review, there was a comment regarding the presence of chemotherapy effect in the breast in only 45% of cases, with formal grading of response in <10%.
Of these, only 55 (8.6%) gave some sort of formal grading of response, with 20 using the Miller Payne grading score, 20 giving a percentage change in cellularity, one stating that there was 'MRD' and 14 stating that there was 'no response'.
As a medical oncologist involved in the care plan of a patient with breast cancer, I would personally like to see a single report with clearly mentioned data points needed for treatment decisions, including pre chemotherapy core biopsy results, formal grading of response to chemotherapy in the breast and axilla and type of axillary surgery done.
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