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The classification of evidence levels and grade of recommendations are given in Appendix 1.
For other pain syndromes, grade of recommendations is C due to the lack of positive controlled studies.
Publications were selected and classified according to their level of evidence (LE) in order to establish the grade of recommendations.
Capital letters denote the grade of recommendations, and categories in brackets refer to the quality of the underlying body of evidence supporting each recommendation.
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Recommendations were based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system.
FASD – fetal alcohol spectrum disorders; GRADE – Grading of Recommendations Assessment, Development and Evaluation [ 21].
The quality of evidence for each outcome was assessed using GRADE (Grading of Recommendations Assessment, Development and Evaluation) [ 19].
The retrieved evidence will be assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.
AMD: Age-related macular degeneration; AREDS Age-relatedd Eye Disease Study; Continuinguing education; GRADE: Grading of Recommendations Assessment, Development and Evaluation; NICE National Institute for Health and Clinical Excellencee.
A first version of recommendations was elaborated using the GRADE method (Grade of Recommendation, Assessment, Development and Evaluation) [ 7, 8].
Evidence quality was assessed using the Cochrane risk of bias tool and GRADE (Grades of Recommendation, Assessment, Development and Evaluation).
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