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Nevertheless, how depletion of regulatory T cells affects exocrine gland dysfunction remains to be established because the grade of infiltration does not correlate with actual dryness.
MRI with administration of gadolinium is capable of reflecting neovascularization and grade of infiltration of bone marrow in patients with diffuse multiple myeloma[ 27 ].
This important point must be realised because there is also no correlation between gland function and grade of infiltration in humans.
We used three human colon cancer cells with distinct degree of differentiation, according to their grade of infiltration or metastasis, in an attempt to represent the variety of cellular changes occurring in precancerous lesions as well as manifest tumors.
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For all cases we reviewed age, gender, ethnicity, location of primary tumor, histological grade, extent of infiltration, lymphatic and venous invasion, and evolution of disease.
15 Antrum and corpus mucosa were evaluated for the grade of leucocytic infiltrations, infiltrate activity, grade of regenerative epithelial replacement and mucus depletion.
Quantitative analysis of 18 F-FDG uptake for the standardized circular region of interest of the infected tibias revealed a relationship between the PET image intensity, the grade of leukocyte infiltration, and the virulence of the inoculated bone pathogen.
The primary SS patients were divided according to their grade of lymphocytic infiltration (grades 1 to 4; described in the Methods).
Foxp3+ T-regulatory cells are mainly represented in the intermediate grade of lymphocytic infiltration and decline in severe histological lesions [ 29, 30].
The features 'fibrosis', 'necrosis' and grade of 'tumour infiltration' were more often present than were other regressive changes (Table 3), and were separately analysed to tentatively investigate which features contributed most to the effect of the overall tumour regression score.
The definition of pangastritis and corpus-predominant gastritis (grade of neutrophil infiltration in the corpus equal or higher than in the antrum) was based on the parameters described in Uemura et al. The distribution of the gastritis parameters is shown in Table 1.
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