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Since no tertiary structure information about Noc4p-homologues or related proteins is available we subdivided the Noc4p-primary structure into several subdomains by other means: the different grade of conservation within distinct parts of Noc4p coding sequences from several eukaryotic species served to classify the polypeptide into eight domains (Fig. 2A)(see also Fig. 1 [28]).
We found an overall high grade of conservation on molecular and cellular mechanisms associated with tissues, diseases and aging that is consistent with previous results [ 8, 52, 53].
For example, in the case of the organism we study in this work (zebrafish), a simple analysis of two classic gene families known to have a very high grade of conservation among their members (homeobox and histone gene families) reveals that, at nucleotide level, values of sequence identity for each pair comparison were up to 80% (e.g., typically in the range of 71 80% in the case of homeobox).
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On the other hand, picTar considers grades of conservation in their prediction algorithm.
panel, another form of conservation.
The region of positive potential, adjacent to the negative ferroxidase site can be attributed to R89 and H47, again variable spots with conservation grade of 3 and 5, respectively (Figure 6A).
The park is a national nature reserve, a Site of Special Scientific Interest and a Special Area of Conservation and is included, at Grade I, on English Heritage's Register of Historic Parks and Gardens of special historic interest in England.
First, think of conservation.
Dept. of Conservation.
Dept. of Conservation, Calif.
Head of Conservation, Mary Rose Trust.
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