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Thus, the ADC values were not calculated to differentiate grade of aggressiveness.
The definition of distinct clinical diseases means that classification by histological grade of aggressiveness is neither helpful nor possible.
For the purposes of determining whether variants within CYP1B1 are associated with the disease aggressiveness, we subdivided the cases of each ethnic group in two subgroups: men with a low grade of aggressiveness (Gleason score <7) and men with a high grade of aggressiveness (Gleason score ≥7).
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In this study, BRC cells with different grades of aggressiveness were cocultured with promonocytes in a Matrigel-based 3D system and upregulation of different genes, often referred to as markers of malignancy, was evaluated.
21, 22 The phenomenon of FDG uptake by prostate cancer cells is variable, mostly depending on the grade of differentiation and aggressiveness: higher FDG uptake can be observed in tumors that are resistant to androgen-deprivation therapy than in androgen-dependent ones.
Depending on their mitotic rate, ependymal tumors fall into three categories, in increasing order of aggressiveness: subependymomas (WHO grade I), ependymomas (WHO grade II) and anaplastic ependymomas (WHO grade III).
iNOS expression has been correlated with increased tumor grade and aggressiveness of breast cancer cells [ 7, 9].
In addition, Wnt3a expression is associated with the clinical grade and aggressiveness of gliomas, and interestingly, it is overexpressed on glioma stem cells [ 48].
These low survival rates may not be surprising considering that patients are disadvantaged regarding almost all the known prognostic factors, such as stage at diagnosis, histological grade and aggressiveness of the disease, availability and accessibility to appropriate treatment modalities and probably age at diagnosis.
Astrocytomas are classified in ascending order of aggressiveness into WHO grades I IV.
HBEGF identified as one of EGF receptor ligands is strongly associated with large tumor size, high histoprognostic grading, and aggressiveness of breast cancer [ 47].
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